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Discussion forum - 49th ERA-EDTA Congress
    Topic - Paediatric nephrology

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Poster: 686
Visits: 600
Title: Does rituximab induce hypogammaglobulinemia in children with steroid dependent idiopathic nephrotic syndrome?
Authors: Tim Ulinski , Letitia Delbe-Bertin
Centre: Department of Pediatric Nephrology, Hpital Trousseau

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DOES RITUXIMAB INDUCE HYPOGAMMAGLOBULINEMIA IN CHILDREN WITH STEROID DEPENDENT IDIOPATHIC NEPHROTIC SYNDROME?

Tim Ulinski
Thread initiator
Subspeciality
Reg: 5/6/2012 12:08:00 PM

 Comment# 1

Rituximab (RTX) seems to be a promising strategy in steroid dependent idiopathic nephrotic syndrome (SDNS) since several years. RTX induces profound depletion of circulating B-cells, suggesting hypogammaglobulinemia (defined as IgG 6 g/L) as a potential side effect after long-term treatment.
Comment added on 5/6/2012 12:09:00 PM 
     
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